Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Milk thistle (PDQ) health professional version. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. It may not be safe for people with hormone-sensitive breast cancer. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. 2014;2014:941085. doi:10.1155/2014/941085. Some people claim it can help to treat: cirrhosis. This stout thistle usually grows in dry, sunny areas. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Some, but not all, milk thistle supplements are vegan. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. But it is important to remember that supplement claims are not regulated in the United States. Dosage is also typically listed on the nutrition label of supplements. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). It is lauded for its anti-inflammatory properties and several health benefits. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. gallbladder disorders. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Usually avoid combinations; use it only under special circumstances. List Milk Thistle Capsule side effects by likelihood and severity. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Milk thistle (PDQ) patient version. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. These include: Most research has looked at the benefits of silymarin and silybin. How long does it take for milk thistle to start working? Possibly. In clinical trials, milk thistle appears to be well tolerated in recommended doses. Milk thistle can also cause an allergic reaction in some people. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. It also seems to have antioxidant and anti-inflammatory effects. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Side effects are always possible when taking supplements. People with diabetes should use caution. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. He has been in the digital media field for over eight years. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Drs. Some people also call it Mary thistle and holy thistle. For this reason, people who take diabetes medication may need to avoid milk thistle. Can you drink alcohol while taking milk thistle? Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Milk thistle is a plant named for the white veins on its large prickly leaves. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. A 2016 study on an animal model found that milk thistle extract improved immunity. Enter other medications to view a detailed report. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. This is not a complete list of side effects and others may occur. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. An important part of taking supplements is proper storage. Milk thistle. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. The terms milk thistle and silymarin are often used interchangeably. We comply with the HONcode standard for trustworthy health information. Otherwise, call a poison control center right away. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. These reactions may occur if you have an allergy to milk thistle. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Milk thistle could play an essential role in supporting bone health. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. 2005 - 2023 WebMD LLC. However, there is no solid evidence that supports these claims. More study is needed to confirm this. Seeff LB, Curto TM, Szabo G, et al. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Taking it along with estrogen pills might reduce their effectiveness. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. How this happens is yet to be studied. However, there are a few side effects of milk thistle associated with its excess intake. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. The most common use of milk thistle is for liver problems. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Adv Ther. Does milk thistle interact with my other drugs? This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. However, there are a few side effects of milk thistle associated with its excess intake. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Other studies looking at milk thistle for cirrhosis have found conflicting results. It is also unknown whether milk thistle is safe for children. Cathy Wong is a nutritionist and wellness expert. Learn more about the other negative effects of this herb and what research says about them. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Milk thistle is native to Europe and was introduced into North America by early colonists. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. This may help ease symptoms from liver . Current studies on milk thistle use a wide range of doses. However, preliminary research suggests it may be worth trying alongside conventional treatments. Scan J Gastroenterol. Milk Thistle; Silybum marianum; St. Mary's Thistle. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. However, the evidence is conflicting. 2008;47(2):605-12. doi:10.1002/hep.22044. MNT is the registered trade mark of Healthline Media. jaundice. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. milk thistle. Avoid combinations; the risk of the interaction outweighs the benefit. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Moderately clinically significant. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. An older study found that milk thistle extract had a positive effect on immune response in humans. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. 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