If you think youre experiencing new or worsening depression or anxiety while taking Femara, talk with your doctor. Factors to consider include those in the list below. This enzyme is the main way that your body makes estrogen after youve gone through menopause. Femara is used in the following ways to treat advanced breast cancer: Femara has been found to be effective in treating advanced breast cancer. Because these drugs work in the same way, their side effects are very similar. Dont take two doses together to make up for a missed dose. What should I know about Femara vs. Arimidex? I was prescribed Letrozole about 6 weeks before my operation, bilateral mastectomy with implants. Also, if you experience fatigue, extreme tiredness, or dizziness while taking Femara, you shouldnt drive or operate heavy machinery. But sometimes Femara is used off-label for other conditions. Some people start taking letrozole after a few years of taking the hormone therapy drug tamoxifen . Learn about the dosage for Femara in treating certain types of breast cancer. But with advanced breast cancer, the cancer has spread to nearby areas or lymph nodes (called locally advanced breast cancer), or it has spread to other parts of the body (called metastatic breast cancer). Femara can interact with some other medications. If youre already ovulating before taking Femara, the drug may cause more eggs than usual to mature and be released from your ovaries. However, if you think youre having a medical emergency, you should call 911 or your local emergency number. You may want to ask about other treatments for breast cancer. (Day 1 of your menstrual cycle is the first of your period.) When talking with your doctor, you may want to ask the following questions: To learn more about breast cancer and its treatment options, sign up for Healthlines breast cancer newsletter. Adjuvant treatment of breast cancer is treatment thats taken to reduce the risk of the cancer coming back after surgery. And some may be easily managed, too. 2005-2023 Healthline Media a Red Ventures Company. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Femara is FDA-approved for adjuvant treatment of early breast cancer thats hormone receptor-positive (HR+). Serious side effects are possible from taking Femara. And this medication doesnt need to be stopped gradually. You may take Letrozole with or without food. Mild side effects of Femara can usually go away within a few days or a couple weeks. Femara is also used off-label to treat infertility. However, statistics show that many people with breast cancer have an excellent chance of. Some people may have an allergic reaction to Femara. Use an effective form of birth control to keep from getting pregnant during . But this side effect wasnt reported in studies. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. How long side effects last can vary from person to person. During clinical studies, both weight gain and weight loss were reported in people who took Femara for breast cancer treatment. Your doctor or pharmacist can tell you about any interactions these items may cause with Femara. * In this article, we use the term female to refer to someones sex assigned at birth. Breast cancer develops when cells in your breast tissue start to grow and multiply more quickly than usual. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. Taking more than the recommended dosage of Femara may result in overdose in some people. Femara may not be right for you if you have certain medical conditions or other factors that affect your health. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. This helps prevent others, including children and pets, from taking the drug by accident. It should be safe to drink alcohol during your Femara treatment. Spotting refers to slight vaginal bleeding when you arent having your period. Female infertility refers to not being able to become or stay pregnant. bone, muscle, or joint pain*. However, its important to note that alcohol and Femara can have similar side effects. Its true that aches and pains are a side effect of Femara, and you may not be able to prevent them entirely. But after menopause, your estrogen levels fall, which can weaken your bones. When estrogen is blocked, the pituitary gland gets a message that it needs to produce follicle-stimulating hormone (FSH), which stimulates the ovary to produce an egg. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. No, Femara isnt a chemotherapy drug. We comply with the HONcode standard for trustworthy health information. If your cholesterol gets too high during your Femara treatment, your doctor may prescribe a cholesterol-lowering medication, such as a statin. The usual dosage of Femara for adjuvant treatment of breast cancer is one tablet taken by mouth once each day. For this purpose, Femara is usually used to help lower the risk of the cancer coming back after its been removed by surgery. If letrozole stops working and your breast cancer comes back, your specialist may prescribe another hormone drug. Can Breast Cancer Be Detected in a Complete Blood Count (CBC)? Osteoporosis. Be sure to always take the dosage of Femara thats prescribed by your doctor. Femara is used to lower the risk of the cancer coming back. Its also worth noting that alcohol is known to increase the risk of developing breast cancer. Novartis, the maker of letrozole, provided funding for the trial, along with NCI and the International Breast Cancer Study Group. When is the best time of day to take letrozole? Most people are given letrozole for 5 years, but some will take it for up to 10 years. Your doctor will explain how you should take Femara, such as how much to take and how often. Femara is sometimes used off-label for this purpose in females* who havent had success with other endometriosis treatments. For details about how side effects for these drugs compare, see the Arimidex vs. letrozole section of this article. Although not all of these side effects may occur, if they do occur they may need medical attention. You should take Femara according to your doctors or another healthcare professionals instructions. You may have questions about Femara and your treatment plan. Its not chemotherapy, which is a type of cancer drug that most commonly causes hair loss. If you have breast cancer, your doctor might prescribe Femara for you. You should avoid drinking large amounts of alcohol while youre taking Femara. Your doctor will order blood tests to check your cholesterol levels before you begin taking Femara and during your treatment. There are also some things you can do to help minimize loss of bone strength while youre taking Femara. You shouldnt drive or operate machinery until you know how the drug will affect you. But sometimes the drug is used off-label in people with this condition. When Femara is used off-label to treat infertility, the drug doesnt increase the risk of birth defects or miscarriage. No, Femara tablets should be swallowed whole. With endometriosis, tissue thats similar to the tissue lining your uterus grows in other parts of your body. Letrozole (Femara ) is a hormonal therapy drug used to treat breast cancer. But this was not one of the most common side effects reported in studies of the drug. If your doctor confirms that you had a mild allergic reaction to Femara, theyll decide if you should continue taking it. Do not stop taking letrozole without talking to your treatment team first. They can recommend healthy ways for you to manage your weight. What can I do to help prevent the aches and pains that Ive heard are a side effect of taking Femara? The expiration date helps guarantee that the medication is effective during this time. Talk with your doctor about how long you should take Femara for adjuvant treatment of breast cancer. Most people who use Femara take the drug for at least 5 years. Some research from 2011 showed that Femara can help manage pain related to endometriosis. One of the possible triggers for this abnormal cell growth is the hormone estrogen. If youre concerned about weight gain during your Femara treatment, talk with your doctor. With early breast cancer, the cancer hasnt spread out of either your breast or the lymph nodes in your armpit. Femara works by stopping the enzyme (type of protein) called aromatase from working like usual. You can take Femara at any time of day. was on it for 10 years!!! Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. They work by lowering estrogen levels within your body, which helps stop the growth of breast cancer. Your doctor may prescribe Femara along with other breast cancer treatments. You can take Femara with or without food. You will therefore start remaking this hormone. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Instead, Femara is a hormone therapy. Call your doctor right away if you have bone pain. Your doctor will help you to weigh potential risks and benefits of taking Femara for a long period of time. Keep reading to learn more. Femara is also FDA-approved for extended adjuvant treatment of early HR+ breast cancer. Liver problems. If your doctor confirms that you had a serious allergic reaction to Femara, they may have you switch to a different treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This stops estrogen from being able to stimulate breast cancer cells to grow and multiply. If you have osteoporosis or risk factors* for developing this condition, talk with your doctor before starting Femara. What Types of Breast Cancer Have the Highest Recurrence Rates? (With off-label use, a drug thats approved to treat one condition is used to treat another.). If you have trouble swallowing Femara tablets, talk with your doctor or pharmacist about ways to help make it easier for you to take your medication. Use of the term male in this article refers to sex assigned at birth. However, there are steps you can take to reduce your risk. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. This is because both animal studies and reports of use by pregnant females* suggest that Femara may cause problems with fetal development (also called birth defects) and miscarriage. Oftentimes women with PCOS dont ovulate as usual, so they have trouble becoming pregnant. How does Arimidex work? Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Femara. The half-life of Femara is about 2 days. These and other important considerations are discussed in more detail below. Femara contains the active drug letrozole, while Clomid contains the active drug clomiphene. Taking a Break From Letrozole Therapy After Breast Cancer. They can recommend you how much alcohol is safe for you to drink during Femara treatment. These side effects are less common side effects (occurring in about 10-29%) of patients receiving Letrozole: Arthralgias (bone and joint pain) Night sweats. . Most of these side effects may go away within a few days or a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist. Generic forms of Femara are available. HR+ breast cancer is encouraged to grow by hormones, including estrogen. Letrozole may be used: What are the mild side effects of Femara? You should always consult your doctor or another healthcare professional before taking any medication. You actually will have a decrease in the effects of the Femara (letrozole) which are joint pain, hot flashes, fatigue and generalized dryness. If so, this article on breast cancer treatment options may be helpful for you. Talk with your doctor about your health history before you take Femara. International guidelines recommend letrozole (the active drug in Femara) as an effective treatment for infertility. Some that are rare (occurring in less than 10% of patients) are not listed here. If you have questions or concerns about this potential side effect, talk with your doctor or pharmacist. After surgery, the women were randomly assigned to one of four groups: 5 years of letrozole (letrozole monotherapy), 5 years of tamoxifen (tamoxifen monotherapy), or one of the two sequential treatment groups. Its a type of drug called an aromatase inhibitor. Off-label drug use is when a drug thats approved for one use is used for a different one thats not approved. Femara tablets contain the active drug letrozole. MNT is the registered trade mark of Healthline Media. Sharing this information can help you avoid potential interactions. Melatonin and Breast Cancer: Is it Safe and Can it Help? Femara comes as 2.5-mg tablets that are taken by mouth. Always check with your doctor or pharmacist before using any herbs or supplement products while youre taking Femara. If youre interested in finding an alternative to Femara, talk with your doctor. Its possible that any side effect of Femara may last throughout your treatment. Some drugs, such as choriogonadotropin alfa (Ovidrel), induce ovulation (just like Femara does). Studies conducted by maxillofacial surgeons have shown that most of the free-flowing chemical in the bloodstream is eliminated in approximately three to four months. (Enzymes help chemical reactions in your body to happen.). With early breast cancer, the cancer hasnt spread out of either your breast or the lymph nodes in your armpit. Its possible that you may continue to have side effects from Femara even after you stop taking it. Nausea. * Sex and gender exist on spectrums. Call your doctor if you think youve taken too much Femara. Use of the term female in this article refers to sex assigned at birth. Femara may not be right for you if you have certain medical conditions or other factors that affect your health. Weight gain was a common side effect in studies of Femara. All rights reserved. You may also gain weight if you have swelling, which is another possible side effect of Femara. Femara is meant to be used as a long-term treatment for breast cancer. Some people may experience mild or serious side effects during their Femara treatment. Here are answers to some frequently asked questions about Femara. Examples of both mild and serious side effects that can occur when using Femara for infertility include: Youll usually take Femara by mouth once daily for 5 days after the start of your menstrual cycle. For oral dosage form (tablets): For breast cancer: Adults2.5 milligrams (mg) once a day. However, there are steps you can take to reduce your risk. (To learn more, see Is Femara used for infertility? right above.) If youre not sure if youll need to get prior authorization for Femara, contact your insurance company. Femara is a type of hormone therapy used to treat breast cancer. In addition to the uses listed above, Femara may be used off-label. Taking Femara can cause high cholesterol in some people. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Blood tests may be needed to check for unwanted effects. You may also be able to ease headaches by applying an ice pack or heating pad to your head. As with most drugs, some people can have an allergic reaction after taking Femara. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. If youre concerned about hair loss while taking Femara, talk with your doctor. For advanced breast cancer, Femara is primarily used for breast cancer thats known to be HR+. If you think youve taken too much of this drug, call your doctor. Femara will start working soon after you start taking it. Femara comes as tablets that you take by mouth. However, alcohol can cause side effects similar to those of Femara. Letrozole is typically taken once a day for five days. These include: Youre more likely to have success with Femara treatment for infertility if your body isnt already ovulating. Femara is classified as an aromatase inhibitor. Costs of prescription drugs can vary depending on many factors. This is how Femara causes ovulation. No, the Food and Drug Administration (FDA) hasnt approved Femara for use in bodybuilding. They can also suggest ways to help reduce side effects. Breast cancer occurs when breast cells grow rapidly and out of control. Breast lumps and visual changes to the breasts or nipples are more frequent signs of breast, Aggressive, hard-to-treat breast cancer types such as inflammatory breast cancer and triple-negative breast cancer are the most likely to recur. These types of therapies stop estrogen from encouraging breast cancer cells to grow. Oftentimes people with PCOS dont ovulate like usual, so they have trouble becoming pregnant. (Off-label use is when a drug thats approved for one condition is used to treat another.) The most common cause of ovulation problems that result in infertility is polycystic ovary syndrome (PCOS). But Femara is also sometimes used to treat infertility that doesnt have an obvious cause. Dont take more Femara than your doctor prescribes. To help make sure that you dont miss a dose, try setting a reminder on your phone. But if it contains estrogen, it may interact with Femara treatment. Femara is a hormone therapy thats used for HR+ breast cancer. You should not stop taking Letrozole without discussing with your physician. One example of an androgen is the hormone testosterone. Femara is used off-label to treat infertility in females. drug can stay in . Femara can be an effective treatment option for certain types of breast cancer. If youd like to know more about how Femara and Arimidex compare with each other, see this detailed breakdown. The Femara dosage your doctor prescribes will depend on several factors. If you no longer need to take Femara and have leftover medication, its important to dispose of it safely. Femara is a prescription drug used in adult females* whove gone through menopause. You shouldnt take Femara unless its been prescribed by a healthcare professional. Such drinks and foods may worsen hot flashes. If you have questions about how Femara may affect your bone density, talk with your doctor. You should keep taking Femara for as long as your doctor recommends. What are some frequently asked questions about Femara? Female hormones that occur naturally in the body can increase the growth of some breast cancers. Heres some detail on several of the side effects this drug cause. (A drug class is a group of medications that work in a similar way.). Femara is a kind of drug called an aromatase inhibitor. Plasma concentrations at steady state are 1.5 to 2 times higher than predicted from the concentrations measured after a single dose, indicating a slight non-linearity in the Femara has been found to be effective in treating early breast cancer. More specifically, Femara is a type of hormone therapy called an aromatase inhibitor. You can also find information on the drugs strength, form, and more. Statistics on breast cancer survival rates by stage, reduced bone mineral density (weakened bones), swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, whether youre using Femara with other fertility treatments, spotting (light vaginal bleeding between periods), rarely, ovarian hyperstimulation syndrome (OHSS), which occurs when more eggs than usual develop in your ovaries, the condition youre taking Femara to treat. Femara comes as tablets that are taken by mouth. Femara and Arimidex (anastrozole) are both used to treat certain types of breast cancer in females* whove gone through menopause. But if you have liver problems, your doctor may recommend that you take the drug once every other day. When you take Femara to induce (cause) ovulation, the drug is cleared from your body within several days after youve stopped taking it. But if they become more severe or dont go away, talk with your doctor or pharmacist. about any long-term side effects from taking Femara, talk with your doctor. Can diet help improve depression symptoms? You should always consult your doctor or another healthcare professional before taking any medication. One 2011 study looked at using doses higher than the current standard dose to treat infertility. My doctor said Femara may cause hot flashes. This is especially helpful when you first start taking new drugs or using a combination of treatments. Chemotherapy describes traditional drugs used to treat cancer. Most doctors wont prescribe Femara for more than six cycles of treatment. It can also interact with certain supplements as well as certain foods. But because most breast cancers are HR+, Femara can also be used to treat advanced breast cancer whose HR status isnt known. If youre not having periods when starting Femara, your doctor will recommend when you should start taking the drug. * However, its sometimes used off-label for this use. If you have questions about the risks of Femara use in pregnancy, talk with your doctor. To find out how often this side effect occurred in clinical studies, see the drugs prescribing information. A CBC can help detect some blood cancers, but it cannot detect breast cancer. Its possible you may have side effects after stopping Femara treatment. Estrogen helps to keep your bones strong. If you have questions or concerns about these potential side effects, talk with your doctor or pharmacist. If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. These symptoms could be life threatening and require immediate medical care. If your doctor gives you the OK, here's a gentle routine to try. Healthline Media does not provide medical advice, diagnosis, or treatment. * However, the drug may be used off-label for this purpose. Femara may cause fatigue (lack of energy) in some people. Precautions. Do I have a higher risk for side effects than other people taking Femara. Stretching and low-impact exercise such as walking can help keep your joints and muscles from aching. * For more information on this side effect, see the Side effect focus section below. I never had any major side effects, just osteporosis but not much and a vegan diet completey took away joint pain. Headaches were a common side effect in studies of Femara. If you have liver problems, your doctor may prescribe a lower dosage of Femara for you. Its used to treat the following types of cancer: Femara comes as a tablet you take by mouth once per day. Keep in mind that side effects of a drug can depend on: Your doctor or pharmacist can tell you more about the potential side effects of Femara. If you drink alcohol and youre concerned about how this might affect your condition, talk with your doctor. Stopping Femara treatment isnt known to cause side effects. If youre concerned about how Femara might affect your cholesterol levels, talk with your doctor. Below are commonly used dosages, but always take the dosage your doctor prescribes. Femara isnt currently approved to treat infertility in females. But serious side effects are more likely to last longer. Femara and clomiphene are both used to stimulate ovulation in females who are having trouble becoming pregnant. This also includes the release of bisphosphonates from bone surfaces that end up in the bloodstream, because they can't attach themselves to the bone cells and are simply unused. If you havent conceived after six treatment cycles with Femara, talk with your doctor about other options for infertility treatment. Different interactions can cause different effects. Femara is approved to treat certain types of early and advanced breast cancer. If you would like to report to the FDA a side effect youve had with Femara, you can do so through MedWatch. Learn. However, this particular treatment approach isnt right for everyone. If youre breastfeeding, talk with your doctor before you start taking Femara. In certain situations, if Femara is no longer working for you, your doctor may have you stop taking the drug. You should always consult your doctor or another healthcare professional before taking any medication. Although theyre not common side effects, in some cases, Femara can cause anxiety or depression. In addition, a small study found that Femara may be effective in treating infertility in men who have both obesity and low testosterone levels. Before taking Femara, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. If you have questions or concerns about changes in your weight, talk with your doctor or pharmacist. (With dependence, your body needs the drug in order to function like usual.) As a type of hormone therapy, Femara works by lowering estrogen levels in your body. Your doctor can recommend treatment options other than Femara. But you wont be able to notice it working in your body. In studies, increased cholesterol levels were one of the most common side effects among people taking Femara. These include: The following information describes dosages that are commonly used or recommended. You can also ask your pharmacist for information on how to dispose of your medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Induce ovulation ( just like Femara does ) statistics show that many with. Take and how often this side effect youve had with Femara treatment isnt known to increase growth! Reactions in your body, which is a type of hormone therapy used to lower risk! Is primarily used for breast cancer occurs when breast cells grow rapidly and out of either your breast the... Use in pregnancy, talk with your doctor if you think youve taken much!, ask your pharmacist for information on this side effect focus section below you may not be able ease! Contains estrogen, it may interact with Femara, be sure to tell your doctor pharmacist. Shown that most commonly causes hair loss your armpit someones sex assigned at.... Chemical reactions in your breast tissue start to grow and multiply more than! 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