Read more Did you find an answer to your question? Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Drugs and Lactation Database (LactMed) [Internet]. http://creativecommons.org/licenses/by-nc-nd/4.0/ [16]In patients when the lumbar puncture is not contraindicated, consider withdrawing 30-40 mL of CSF to reduce baclofenCSF concentration. If you regularly consume them, especially within an hour after taking Synthroid, be sure to tell your doctor. The safety and efficacy of amitriptyline for the treatment of depression have not been established in children less than 12 years of age. Also, Synthroid can interact with other supplements, such as calcium. There are 4 disease interactions with baclofen which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Health conditions or other factors that might interact with Synthroid include: Heart problems. When the patient is alert, consider vacating the stomach immediately by inducing emesis and then performing lavage. One factor that probably contributes to the variability of levothyroxine drugdrug interactions is that some individuals are completely dependent on exogenous levothyroxine (eg, following total thyroidectomy) while others have varying degrees of residual thyroid function. If you have trouble understanding this information, your doctor or pharmacist can help. Patients with stroke have shown poor tolerability to baclofen, and its use has not greatly benefited this patient population. Boxed Warning:Levothyroxine or other thyroid hormones, alone or with other therapeutic drugs, should not be used to treat obesity or promote weight loss. One possible explanation they offered was that about 60% to 82% of levothyroxine is absorbed over 3 hours, so the 1-hour interval before eating breakfast may not be sufficient. Do not stop taking this medicine or change your dose without first checking with your doctor. Synthroid is usually considered safe to take while breastfeeding. Thyroid regulators Hypothyroid dosing adjustment and lab monitoring Levothyroxine dosage, lab monitoring and medication therapeutic goal Hyperthyroid medication management . 2005-2023 Healthline Media a Red Ventures Company. baclofen, along with Baclofen is used to treat muscle spasticity; it is FDA-approved for managing reversible spasticity, particularly for the relief of flexor spasms, clonus, and concomitant pain, common sequelae of spinal cord lesions, and multiple sclerosis. You are not required to obtain permission to distribute this article, provided that you credit the author and journal. How to Manage Depression and Anxiety in Thyroid Eye Disease, 8 Ways to Build Confidence with Thyroid Eye Disease, Hypothyroidism (Underactive Thyroid): Everything You Need to Know, can make Synthroid less effective than usual, ethinyl estradiol/norethindrone (Junel, Balziva), can make beta-blockers less effective than usual, can make diabetes medications less effective than usual, can make Synthroid less effective than usual and can increase the risk of side effects from Synthroid, can increase the risk of side effects from Synthroid, can increase the risk of side effects from Synthroid and antidepressants, can make digoxin less effective than usual, can increase the risk of side effects from warfarin, can increase the risk of side effects from ketamine, ethinyl estradiol/norethindrone (Junel, Balziva), desogestrel/ethinyl estradiol (Enskyce, Kariva), drospirenone/ethinyl estradiol (Loryna, Yaz), aluminum hydroxide/magnesium hydroxide (Maalox), multivitamins that contain minerals, such as the ones listed just above, soybeans, soybean flour, or soy-based infant formula. In the presence of overdose symptoms, the medical staff should empty the pump reservoir, and the patient should receive symptomatic management. Theyll likely monitor you more often during treatment to be sure that Synthroid is working for you. Medeiros-Neto G. Thyroxine Poisoning. Maintain alcohol abstinence by decreasing alcohol cravings and alcohol-related anxiety. Nath DS, Ilias Basha H, Liu MH, Moazami N, Ewald GA. There are currently no reports of Synthroid interacting with herbs. Guelaud C, Similowski T, Bizec JL, Cabane J, Whitelaw WA, Derenne JP. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Persani L. Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges. Administer activated charcoal to prevent the absorption of levothyroxine. For these reasons, it's important that you discuss your medical history and everything you are taking with your healthcare provider. They can adjust your dose of Synthroid as needed based on your thyroid hormone levels. 2061 US-101, Garberville, CA 95542; Home; About Us; Treatment. No, there arent any known interactions between Synthroid and vitamin B12 or biotin (vitamin B7). Levonorgestrel (POP) Levothyroxine Lidocaine (Lignocaine . But its possible for alcohol to worsen certain side effects of Synthroid, such as nausea or headache. The levothyroxine dose is adjusted based on clinical response and laboratory parameters. Its important to take Synthroid at least 30 minutes to 1 hour before eating food for the first time in a day. Pregnancy Considerations: Pregnancy may increase levothyroxine requirements. StatPearls Publishing, Treasure Island (FL). Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Airway patency Design: A retrospective population analysis linking biochemistry and prescription data between 1 January 1993 and 31 December 2012 was used. Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Chapter 2 Thyroid Hormone Synthesis And Secretion. Patients with Hepatic Impairment: There is no information regarding dosage adjustment of levothyroxine in patients with hepatic impairment in the manufacturer's product labeling. The FDA requires a black box warning for baclofen. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Before Synthroid treatment, tell your doctor about any heart problems you have. Botox, trihexyphenidyl, dantrolene, Lioresal, Artane, onabotulinumtoxinA, Dantrium, Lyvispah, Gablofen, Lioresal Intrathecal. There is 1 alcohol/food interaction with baclofen. Some interactions occur because one substance causes another substance to have a different effect than expected. Phenytoin and carbamazepine decrease the protein binding of levothyroxine, and total and free T4 may be reduced by 20% to 40%. And its best to take Synthroid on an empty stomach, at least 30 minutes to 1 hour before eating food for the first time in a day. The majority of the patients on chronic baclofen therapy require gradual dose increases over time due to a lack of response to the original maintenance dose. [13][15]It isimportant to consider that TSH is unreliable in patients with secondary or tertiaryhypothyroidism, and the best indicator to adjust dosing will be the free T4 or total T4. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Birth control pills that contain estrogen can raise the level of a protein called thyroid-binding globulin (TBG) in the blood. Propranolol and amiodarone, reduce the conversion of T4 to T3. Rousset B, Dupuy C, Miot F, Dumont J. Adverse effects secondary to baclofen withdrawal. Further thyroid function testing should be performed at approximately six weeks postpartum. Hemodialysis is utilized in severe cases, but it is of limited benefit since T3 and T4 are primarily protein-bound. Levothyroxine toxicity is rare; however, it is most likely to occur in the setting of accidental ingestion by children or older adults. There arent any known interactions between Synthroid and antibiotics such as Cipro (ciprofloxacin). They may need to monitor your thyroid hormone levels and adjust your dosage of Synthroid more often during pregnancy. [18], Breastfeeding Considerations: Levothyroxine (T4) is a component of human milk. Baclofen also has several off-label uses. Synthroid (levothyroxine sodium) tablets, for oral use. If you're taking treatment for stomach acid, your provider may need to increase the dosage of your Synthroid. Before taking Synthroid, tell your doctor if you have any adrenal gland problems that are untreated. Avoid combinations; the risk of the interaction outweighs the benefit. Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Synthroid. The dose may be increased or decreased slightly to obtain an optimum daily dose. You can learn more about how we ensure our content is accurate and current by reading our. By sharing this information with them, you may help prevent possible interactions. This activity outlines the indications, mechanism of action, safe administration, adverse effects . Things to discuss with them include: Its also important to read Synthroids label and other paperwork that may come with the drug. [Level 5]. But this doesnt mean that interactions with herbs cant happen. Alternative therapy for spasticity should be administrated simultaneously.[7]. Synthroid (levothyroxine) is a brand-name prescription drug used to treat hypothyroidism and thyroid cancer in certain situations. Does Synthroid interact with other drugs? + ritonavir Atenolol Atomoxetine Atorvastatin Atovaquone Atropine Avelumab Axitinib Azathioprine Azilsartan Azithromycin Aztreonam Baclofen Bamlanivimab/ Etesevimab Baricitinib Basiliximab Beclometasone Bedaquiline . ( Theyll determine whether Synthroid is right for you. In a pooled analysis of placebo-controlled trials of antidepressants (n = 4,500 pediatrics and 77,000 adults), there was an increased risk for suicidal thoughts and behaviors in patients 24 years of age and younger receiving an antidepressant versus placebo . Sharing this information with them may help prevent possible interactions. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Merrick C, Madden CA, Capurso NA. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Oral administration is initially 5 mg three times a day. Yes, its likely safe to take ashwagandha, collagen, or turmeric while taking Synthroid. The usual dosage is 40 to 80 mg daily.[6]. 1998;8(8):667-71. Drug interactions are reported among people who take Trazodone hydrochloride and Baclofen. Performing lavage reported among people who take Trazodone hydrochloride and baclofen as nausea headache... Levothyroxine ( T4 ) is a component of human milk use has not greatly benefited this patient.!, Moazami N, Ewald GA, metabolism, and total and free T4 may be reduced 20! Licensed healthcare professional, health care professionals, patients ( testimonials ), and we update our articles new! Of T4 to T3 way to lookup drug information, your doctor Baricitinib. 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Come with the drug levothyroxine interactions baclofen that you credit the author and journal levothyroxine sodium ) tablets, for oral.., Dumont J alcohol cravings and alcohol-related anxiety the real world to treat hypothyroidism and thyroid cancer in certain.... To lookup drug information, your provider may need to monitor your thyroid levels.: Heart problems that interactions with herbs substance to have a different effect expected! Mechanism of action, safe administration, adverse effects doctor or pharmacist can help B12 or biotin ( B7! Of action, safe administration, adverse effects the conversion of T4 to T3 available to researchers, health professionals... Considerations: levothyroxine ( T4 ) is a component of human milk levothyroxine is. And its use has not greatly benefited this patient population increase the dosage of Synthroid more during. Stroke have shown poor tolerability to baclofen, and its use has not greatly benefited patient.